Monday, June 6, 2011

Somber milestones.


Unites States Centers for Disease Control, MMWR Report June 5, 1981:


Epidemiologic Notes and Reports

Pneumocystis Pneumonia --- Los Angeles

In the period October 1980-May 1981, 5 young men, all active homosexuals, were treated for biopsy-confirmed Pneumocystis carinii pneumonia at 3 different hospitals in Los Angeles, California. Two of the patients died. All 5 patients had laboratory-confirmed previous or current cytomegalovirus (CMV) infection and candidal mucosal infection. Case reports of these patients follow.

Patient 1: A previously healthy 33-year-old man developed P. carinii pneumonia and oral mucosal candidiasis in March 1981 after a 2-month history of fever associated with elevated liver enzymes, leukopenia, and CMV viruria. The serum complement-fixation CMV titer in October 1980 was 256; in may 1981 it was 32.* The patient's condition deteriorated despite courses of treatment with trimethoprim-sulfamethoxazole (TMP/SMX), pentamidine, and acyclovir. He died May 3, and postmortem examination showed residual P. carinii and CMV pneumonia, but no evidence of neoplasia.
NAMES Project AIDS Memorial Quilt
Patient 2: A previously healthy 30-year-old man developed p. carinii pneumonia in April 1981 after a 5-month history of fever each day and of elevated liver-function tests, CMV viruria, and documented seroconversion to CMV, i.e., an acute-phase titer of 16 and a convalescent-phase titer of 28* in anticomplement immunofluorescence tests. Other features of his illness included leukopenia and mucosal candidiasis. His pneumonia responded to a course of intravenous TMP/.SMX, but, as of the latest reports, he continues to have a fever each day.

Patient 3: A 30-year-old man was well until January 1981 when he developed esophageal and oral candidiasis that responded to Amphotericin B treatment. He was hospitalized in February 1981 for P. carinii pneumonia that responded to TMP/SMX. His esophageal candidiasis recurred after the pneumonia was diagnosed, and he was again given Amphotericin B. The CMV complement-fixation titer in March 1981 was 8. Material from an esophageal biopsy was positive for CMV.

Patient 4: A 29-year-old man developed P. carinii pneumonia in February 1981. He had had Hodgkins disease 3 years earlier, but had been successfully treated with radiation therapy alone. He did not improve after being given intravenous TMP/SMX and corticosteroids and died in March. Postmortem examination showed no evidence of Hodgkins disease, but P. carinii and CMV were found in lung tissue.

Patient 5: A previously healthy 36-year-old man with clinically diagnosed CMV infection in September 1980 was seen in April 1981 because of a 4-month history of fever, dyspnea, and cough. On admission he was found to have P. carinii pneumonia, oral candidiasis, and CMV retinitis. A complement-fixation CMV titer in April 1981 was 128. The patient has been treated with 2 short courses of TMP/SMX that have been limited because of a sulfa-induced neutropenia. He is being treated for candidiasis with topical nystatin.

The diagnosis of Pneumocystis pneumonia was confirmed for all 5 patients antemortem by closed or open lung biopsy. The patients did not know each other and had no known common contacts or knowledge of sexual partners who had had similar illnesses. Two of the 5 reported having frequent homosexual contacts with various partners. All 5 reported using inhalant drugs, and 1 reported parenteral drug abuse. Three patients had profoundly depressed in vitro proliferative responses to mitogens and antigens. Lymphocyte studies were not performed on the other 2 patients.



So publicly,  30 years ago Sunday began the AIDS epidemic; one of the most destructive diseases in human history. 

Over one million people are living with AIDS in the United States and over 600,000 have died from the disease in this country. Worldwide around 60 million have been infected and 25 million deaths have occurred.


6 comments:

  1. As I recall, Ronald Reagan never mentioned AIDS as president.

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  2. You're sort of correct. It was April 2, 1987. Way too late. From http://www.actupny.org/reports/reagan.html



    41,027 persons are dead and
    71,176 persons diagnosed with AIDS in the US.


    After years of negligent silence, President Ronald Reagan finally uses the word "AIDS" in public. He sided with his Education Secretary William Bennett and other conservatives who said the Government should not provide sex education information. (They are still saying it!)

    On April 2, 1987, Reagan said: "How that information is used must be up to schools and parents, not government. But let's be honest with ourselves, AIDS information can not be what some call 'value neutral.' After all, when it comes to preventing AIDS, don't medicine and morality teach the same lessons."

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  3. Hedge funds grabbing land in Africa: http://www.bbc.co.uk/news/world-africa-13688683

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  4. great - so we can expect evictions.

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  5. Il have to find why I thought he mentioned AIDS then. I must have read it somewhere.

    Ronald Reagan cared more about UFOs than AIDS

    The president mentions in a 1985 diary entry, in passing, that Rock Hudson was rumored to have AIDS -- and the topic doesn't come up again for two years. (And for some reason, late in his term, he begins consistently misspelling it, as "Aides.") ( http://www.salon.com/news/politics/war_room/2011/02/04/reagan_aides_ufos )

    Aides - marvelous.

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  6. here :

    http://www.aegis.com/topics/timeline/default.asp

    they were not really formal public pronouncements.

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